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THURSDAY, March 17 (HealthDay News) -- A newborn psychotherapy confirms that those who verify the diabetes take Avandia are more probable to develop heart problems and expire than those who verify a kindred identify of diabetes medication.

"The effect on open upbeat haw be considerable," the psychotherapy authors wrote.

Avandia (rosiglitazone) helps curb blood sugar levels in the body, and is formal for patients with identify 2 diabetes. Studies in recent years hit differed most whether it boosts the venture of hunch disease and death.

In response to ontogeny concerns over the drug's cardiovascular effects, U.S. upbeat officials in Sept restricted the ingest of Avandia to patients with identify 2 diabetes who cannot curb their disease on other medications.

In the newborn analysis, researchers looked at the results of 16 studies that participating 810,000 users of Avandia or Actos (pioglitazone), a kindred diabetes medication. The findings materialize online March 17 in the BMJ.

The researchers institute a "modest but statistically momentous increase" in the odds of destined hunch conditions in those who took Avandia. The risk of hunch move chromatic by 16 proportionality and increased 23 proportionality for congestive hunch failure. Overall, mortality rates chromatic 14 percent.

Avandia is a ordinary drug, with most 3.8 million prescriptions a assemblage in the United States.

The psychotherapy authors cautioned that Actos carries its possess risks. Like Avandia, it's been linked to a raise of venture of fracture in women. And researchers worry that it haw slightly increase the venture of bladder cancer.

"Patients should review this think with their physician to acquire a better discernment of how their personal circumstances haw or haw not be reflected in the study, and speech to their physicians most the risks versus the benefit of attractive the drug," said Dr. Debra Wertz, outcomes research trainer for HealthCore Inc., the research subsidiary of the insurance company WellPoint.

Wertz co-authored a 2010 think that institute no momentous differences in risk of hunch attack, hunch unfortunate or modification in patients who took the two drugs.

"One thing to study is that the HealthCore think evaluated a population that is commercially insured and potentially junior [most were under 65] and healthier" than the studies analyzed in the meta-analysis, Wertz noted.

More information

For more most diabetes, essay the U.S. National Library of Medicine.

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