Allergy Drug May Speed Up Kids' Ability to Tolerate Milk (HealthDay)

Wednesday, March 23, 2011 12:01 AM By dwi

MONDAY, March 21 (HealthDay News) -- Kids who are hypersensitised to milk haw be healthy to apace develop temperament by connector the allergy medication Xolair with a gradual impact in their exposure to milk, known as sensitization, a new study suggests.

An estimated 3 meg children in the United States are hypersensitised to some category of food. Milk allergy is the most common matter allergy among children, moving about 2.5 proportionality of those younger than 3.

Treatment supported on predisposition alone -- exposing children to diminutive but progressively greater amounts of the matter center to which they're allergic -- is ofttimes successful. But it's usually a slow impact that runs the venture of provoking hypersensitised reactions.

Seeking a faster and safer method, the research team tested a dual approach -- predisposition along with Xolair (omalizumab), a take that blocks the state of IgE, a natural center in the embody that causes allergic reactions -- in a diminutive group of children. Their findings were to be presented Monday in San Francisco at the period gathering of the American Academy of Allergy, Asthma and Immunology.

Experts state that research presented at meetings should be thoughtful preliminary because it has not been subjected to the demanding scrutiny given to research publicised in medical journals.

Treating concentrate allergies "could change a child's style for the better," Dr. Dale Umetsu, a medicine academic at altruist Medical School and Children's Hospital Beantown and a co-author of the study, said in a news promulgation from the Stanford University School of Medicine, which also participated in the research. "These children had significant concentrate allergy, and were implausible to grow it without whatever identify of treatment."

"While we recognize that large trials are necessary, these results are very promising and declare that a fast and innocuous method of matter desensitization might be acquirable for patients in the near future," Umetsu said.

For the study, the children were first presented injections of Xolair. Over the incoming heptad to 10 weeks, they were unclothed to incrementally crescendo amounts of milk, while continuing communication with the drug. Then, the medication was stopped but the desensitization -- in the form of drinking about two ounces of concentrate a period -- continuing for another octad weeks.

The researchers noted that every of the children complete the flooded treatment process, which they attributed to adding an allergy take to the desensitization regimen. The take acts as a "protective blanket," Dr. Kari Nadeau, an allergist and assistant academic of medicine at Stanford and a study co-author, said in the news release.

"Without this treatment, 10 to 20 proportionality of grouping who move oral immunotherapy modify out, in part cod to intolerable hypersensitised reactions early in the treatment," he said.

At the end of treatment, nine of the eleven children could spend up to 12 ounces of dairy products a period with little or no difficulty, the study found.

"When you essay to go on a fasting that is completely free of milk, it is very difficult because many foods hit a little bit of concentrate protein in them," Nadeau noted. "From a practical standpoint, this communication allowed these patients to impact every types of concentrate products in their diets: They were healthy to take yogurt, cheese, bread, a muffin. One patient in our study said, 'I crapper eventually take cyprinid crackers.'"

Dr. Jonathan Field, director emeritus of the medicine allergy immunology clinic at New royalty University School of Medicine/Bellevue Medical Center in New royalty City, described the findings as both "interesting" and "encouraging."

"The warning is that so far Xolair hasn't been authorised for children under 12," he noted. "But immunologically, it makes sense. And this method may promote a safer matter desensitization process, which crapper sometimes entail risk. So anything that crapper attain it a safer impact would be quite welcome."

More information

The Nemours Foundation has more on concentrate allergy in children.


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