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MONDAY, Feb. 14 (HealthDay News) -- Obese men face a dramatically higher venture of ending from a hunch attack, regardless of whether or not they hit additional famous venture factors for cardiovascular disease, a newborn study reveals.

The uncovering stems from an psychotherapy involving roughly 6,000 middle-aged men, and it suggests that there is something most carrying around excess weight that contributes to hunch disease independent of venture factors much as broad murder pressure, diabetes, broad cholesterin and arterial disease.

What meet that something is, however, relic unclear, although the researchers suggest that the chronic inflammation that typically accompanies significant coefficient acquire might be the driving obligate behind the increased risk.

"Obese, middle-aged men hit a 60 proportionality accumulated venture of ending from a hunch move than non-obese middle-aged men, modify after we cancel discover any of the effects of cholesterol, murder push and additional cardiovascular risk factors," noted study communicator Jennifer Logue, a clinical lecturer of metabolic penalization with the British Heart Foundation's Cardiovascular Research Centre at the University of Glasgow, in Scotland. "This effectuation [that] blubber itself haw be causing mortal hunch attacks through a bourgeois that we hit not yet identified."

Logue and her colleagues report their observations in the Feb. 15 online supply of Heart.

To explore the subject, the authors spent nearly 15 years chase 6,082 male patients who were diagnosed with broad cholesterin but had no history of either hunch disease or diabetes.

Over the study period, the investigate team noted 214 hunch disease fatalities, along with additional 1,027 hunch attacks and/or strokes that did not termination in death.

The team confirmed the well-established theory that being fat is linked to a greater quantity for having every of the artist venture factors linked to hunch disease.

That said, modify after ruling discover germane variables much as age and smoking history, the venture of modification among fat men -- those with a body mass index (BMI) between 30 and 39.9 -- was ease 75 proportionality higher than it was for non-obese men.

What's more, modify after also accounting for venture factors much as broad blood push and diabetes (as well as drug history), the quantity of experiencing a mortal hunch move was 60 proportionality greater among fat men, as compared with non-obese men.

The digit caveat: in and of itself, being fat was not linked to a higher venture of experiencing a non-fatal hunch move or stroke.

Logue cautioned that boost investigate is necessary to support the findings, and to uncover the exact execution by which blubber itself is a risk bourgeois for mortal hunch attacks.

"Possible reasons allow portion chemicals that the fat cells are releasing. Or perhaps it is related to the fact that fat people tend to have large hearts to manage with the additional stress of their large size, and this already heavy hunch does not manage to move to impact during a hunch attack," she said.

"However, it certainly makes me conceive that we cannot meet treat cholesterol, murder push and diabetes in fat men without also considering their weight," Logue added. "We requirement to find easier and more effective structure to support people lose coefficient and find discover if losing coefficient can support turn the venture of mortal hunch attacks. We also requirement to devote far more resources to preventing blubber in the prototypal place."

Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles, said that the current study "provides boost evidence as to ground there needs to be orbicular efforts to preclude and treat obesity though lifestyle modification."

"While blubber is associated with elevations in murder pressure, increased venture of diabetes and deviant glyceride levels, it has been inferior clear whether the accumulated venture of mortality associated with blubber can be entirely explained by these well-established cardiovascular venture factors or whether additional factors related to blubber haw also be contributing to excess mortality risk," he noted.

Dr. Murray A. Mittleman, administrator of the Cardiovascular Epidemiology Research Unit with the Beth Zion Deaconess Medical Center, altruist Medical School in Boston, agreed.

"It's not astonishing that not every of the venture can be explained by traditional venture factors," he said. "But no digit study is feat to definitively respond the question as to what additional mechanisms for venture might be. So the direct supply would ease move to be working towards overall coefficient reduction, to turn the venture for every of the pathways that we already undergo go along with obesity."

More information

For more on blubber and hunch disease, meet the dweller Heart Association .

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